Ingredients
Below is a deep-dive into each key active in NADYN—explaining what it does, how it works, and the clinical evidence behind its inclusion.
Peptan® B Hydrolyzed Collagen Peptides (Types I & III)
Origin & Form: Peptan® is a patented bovine collagen peptide produced by Rousselot—a global leader in collagen research. Using a proprietary multi-step enzymatic hydrolysis, full-length collagen is broken into short chains (2–5 kDa), which studies show are absorbed two- to three-times faster than un-hydrolyzed protein.
Why It’s So Good:
Rapid Uptake: Hydrolyzed peptides appear in human blood within 30–60 minutes.
Skin Benefits: A randomized trial of 10 g/day Peptan® over eight weeks increased skin firmness by 15 % and reduced wrinkle depth by 20 %.
Joint Support: In athletes, 10 g/day improved recovery and reduced exercise-induced joint discomfort by 25 %.
Colartix® B Hydrolyzed Cartilage Peptides (Type II)
Origin & Form: Colartix® B from Bioiberica is a low-molecular-weight peptide extract derived from bovine cartilage. Hydrolysis yields bioactive Type II fragments that mimic natural cartilage breakdown signals.
Why It’s So Good:
Chondrocyte Signaling: At just 25 mg/day, Colartix® Type II peptides have been shown to upregulate proteoglycan synthesis in cartilage cells.
Clinical Relief: Subjects with mild osteoarthritis taking 40 mg/day reported 30 % less stiffness and improved joint function in 60 days.
Nicotinamide Riboside (NR)
Origin & Form: NR is a patented NAD⁺ precursor developed by ChromaDex under the trademark Tru Niagen®. It’s a crystalline, water-soluble form of vitamin B3.
Why It’s So Good:
Best-In-Class NAD⁺ Boost: 300–1 000 mg/day NR elevates blood NAD⁺ levels by up to 80 % in two weeks.
Mitochondrial & DNA Repair: Elevated NAD⁺ activates sirtuin pathways (SIRT1/3), enhancing mitochondrial biogenesis and supporting genomic stability.
Metabolic Health: NR supplementation improves insulin sensitivity and muscle function in older adults.
Liposomal Vitamin C
Origin & Form: Our liposomal vitamin C is produced via micro-encapsulation in phospholipid vesicles, based on technology pioneered by LivOn Labs.
Why It’s So Good:
Superior Absorption: Liposomal delivery achieves 2–3× higher peak plasma ascorbate levels compared to standard ascorbic acid.
Collagen Cofactor: Ascorbate is essential for prolyl- and lysyl-hydroxylase activity in collagen formation—accelerating dermal matrix repair.
BioPerine® (Black Pepper Extract)
Origin & Form: Standardized piperine extract from Sabinsa Corporation, supplied as 95 % pure piperine.
Why It’s So Good:
Bioavailability Enhancer: Human studies show piperine increases curcumin absorption by roughly 200 % and enhances uptake of other botanicals and nutrients.
Aquamin® Magnesium
Origin & Form: Marine-sourced multi-mineral complex from red seaweed (Lithothamnion). Provides 12 % elemental magnesium alongside calcium, strontium and trace minerals.
Why It’s So Good:
Bone & Mineral Synergy: 1 500–2 500 mg/day Aquamin® improves bone mineral density by 5 % over 12 months.
Metabolic & Muscular Support: Delivers a broad spectrum of cofactors in their natural ionic forms—enhancing enzymatic activities in metabolism and muscle function.
Sodium Hyaluronate & Glucosamine Sulfate
Sodium Hyaluronate: Low-molecular-weight (1.5–2 MDa) HA that penetrates tissues to hydrate skin (25 % boost in moisture) and lubricate joints.
Glucosamine Sulfate 2 KCl: The gold-standard 1 500 mg/day dose supports cartilage GAG production and eases joint discomfort by 30 % over 12 weeks.
Optimized Antioxidant Matrix
Turmeric Extract (95 % Curcuminoids) + BioPerine®: 900 mg curcuminoids/day lowers CRP inflammation markers by 30 %.
Grape Seed OPCs & Green Tea EGCG: OPCs and EGCG synergize to protect vessels and skin from oxidative damage.
Alpha-Lipoic Acid & CoQ₁₀: ALA recycles antioxidants and supports mitochondrial health; CoQ₁₀ enhances ATP production and cardiomyocyte function.
Advanced Cofactors & Adaptogens
Vitamins D₃ & K₂: Synergize to improve calcium absorption and direct it to bone—reducing arterial calcification.
Choline, B₁₂ & Folate: Optimize methylation, homocysteine balance, and neurotransmitter synthesis.
Rhodiola, Glycine & SR Magnesium: Clinically shown to reduce stress fatigue by 20 % and improve sleep quality (35 % more deep sleep).